Not known Factual Statements About sodium pentobarbital pentobarbital
Not known Factual Statements About sodium pentobarbital pentobarbital
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pentobarbital will minimize the level or effect of saxagliptin by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
pentobarbital will lower the extent or effect of conjugated estrogens by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
pentobarbital will reduce the extent or effect of bosentan by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Mysterious.
Remedy of overdosage is principally supportive and includes the subsequent: Routine maintenance of an suitable airway, with assisted respiration and oxygen administration as important. Monitoring of essential signs and fluid harmony. Fluid therapy and other regular cure for shock, if desired. If renal function is typical, pressured diuresis might assist inside the elimination on the barbiturate. Alkalinization of your urine raises renal excretion of some barbiturates, Primarily phenobarbital, also aprobarbital and mephobarbital (which can be metabolized to phenobarbital).
Phenytoin, sodium valproate, valproic acid: The effect of barbiturates about the metabolism of phenytoin appears to get variable. Some investigators report an accelerating effect, while others report no effect. Since the effect of barbiturates to the metabolism of phenytoin is not really predictable, phenytoin and barbiturate blood ranges should be monitored much more routinely if these drugs are specified concurrently.
pentobarbital will reduce the level or effect of roflumilast by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration not proposed; powerful cytochrome P450 enzyme inducers lower systemic publicity to roflumilast and should decrease the therapeutic effectiveness
Monoamine oxidase inhibitors (MAOI): MAOI prolong the effects of barbiturates likely since metabolism with the barbiturate is inhibited.
pentobarbital will reduce the extent or effect of elagolix by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use get more info Warning/Check.
pentobarbital will lessen the extent or effect of nilotinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
pentobarbital will lower the extent or effect of estrogens conjugated synthetic by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.
pentobarbital will reduce the extent or effect of lonafarnib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Lonafarnib can be a sensitive CYP3A4 substrate. Coadministration with powerful or average CYP3A4 inducers is contraindicated.
pentobarbital will increase the amount or effect of ivosidenib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration of ivosidenib with powerful CYP3A4 inducers decreased ivosidenib plasma concentrations.
pentobarbital will decrease the level or effect of tofacitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Lack of, or reduced response to tofacitinib may well occur when coadministered with potent CYP3A4 inducers
pentobarbital will reduce the extent or effect of clozapine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.